The genetic information encoded in DNA is read off in living cells through the processes of 'transcription' and 'translation.' The gene produces mRNA molecules (transcription), and mRNAs make proteins (translation) using other macromolecules' help. One fact of life is that these molecular processes are 'noisy.' There are cell-to-cell variations in the mRNA and protein copy numbers even when cells are genetically identical. This noise arguably is a source of 'phenotypic diversity'. We are interested in how molecular regulation affects gene expression noise.
Previously we investigated how molecular competition for transcription factors affects gene expression noise. We are now looking at post-transcriptional regulation of the gene expression by micro-RNAs. Micro-RNAs are small non-coding RNAs that bind to large mRNA molecules and inhibit translation. We are developing stochastic models for micro-RNA mediated negative feedback loops.
Theoretical & Physical Biology Group
BS-MS students are welcome to contribute in the following projects:
Cell tracking & analysis of motion in border cell migration:
The overall aim is to understand how cells integrate multiple guidance cues during migration. This project will involve the acquisition and analysis of experimental videos of cell motion in close collaboration with the Fly lab (Co-PI: Mohit prasad).
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Measuring length distributions of dynamic actin filaments:
The aim here is to understand how size (length) is regulated in dynamics cytoskeletal filaments via molecular processes. This work demands in vitro nucleation experiments followed by imaging (in ) and subsequent analysis in collaboration with Actin Cytoskeleton Research Lab (Co-PI: Sankar Maiti).
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Population dynamics of interacting microbes in changing environment:
Here the overarching aim is to decipher bacterial predator-prey interactions mediated by unique secretion systems in a gut-like environment. This work requires experiments with bacterial co-cultures followed by colony counts in various environmental conditions. This project will evolve in collaboration with the Host-Pathogen Interaction Lab (Co-PI: Amirul I. Mallick).
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NOTE: All the works mentioned above will progress in parallel with theory and model building in our lab. Projects will have both computational and experimental components. Students are expected to spend time in the theory lab as well as in the experimental lab of our collaborators.
Contact Us
Potential PhD/IPhD/external project candidates are always welcome! Please directly email the PI for inquiries regarding the on-going projects.
Address :
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Indian Institute of Science Education And Research (IISER) Kolkata, Mohanpur,
Nadia - 741 246,
West Bengal, India.