The genetic information encoded in DNA is read off in living cells through the processes of 'transcription' and 'translation.' The gene produces mRNA molecules (transcription), and mRNAs make proteins (translation) using other macromolecules' help. One fact of life is that these molecular processes are 'noisy.' There are cell-to-cell variations in the mRNA and protein copy numbers even when cells are genetically identical. This noise arguably is a source of 'phenotypic diversity'. We are interested in how molecular regulation affects gene expression noise.
Previously we investigated how molecular competition for transcription factors affects gene expression noise. We are now looking at post-transcriptional regulation of the gene expression by micro-RNAs. Micro-RNAs are small non-coding RNAs that bind to large mRNA molecules and inhibit translation. We are developing stochastic models for micro-RNA mediated negative feedback loops.
Theoretical & Physical Biology Group
About Us
After - Covid-19, Lab maintaining social distancing
We try to make theoretical and computational models of biological processes at all scales, including subcellular processes of gene expressions and organelle biogenesis, the motion of cell collectives and tissue mechanics during embryonic development, and population dynamics of interacting species. Apart from developing theoretical frameworks, we also enjoy analyzing experimental data to check our predictions, working closely with experimental biologists. The methods we use are primarily based on statistical physics and theories of stochastic processes and probability.
Students with backgrounds in physics, applied mathematics, and computer science who are intrigued (or at least wonder!) about the questions of 'life' are always welcome. Biology students having a deep interest in quantification and unification of data through modeling are also welcome to pursue collaborative projects with experimental labs